New blood test from Cologne: Early detection of kidney diseases revolutionized!
New blood test from Cologne: Early detection of kidney diseases revolutionized!
The University Hospital Cologne has achieved significant progress in the diagnosis of kidney diseases. An interdisciplinary research team has developed an innovative blood test to improve the forecast of autosomal dominant polycystic kidney disease (ADPKD). This exciting study was published in the renowned specialist journal Nature Communications and is entitled "Developing Serum Proteomics Based Prediction Models of Disease Program.
By analyzing over 1,000 blood samples from one of the largest ADPKD cohorts worldwide, 29 proteins were identified that correlate with the progression of the disease. These biomarkers are related to important immunological processes and the metabolism. Univ.-Prof. Dr. Roman Ulrich Müller and Dr. Philipp Antczak from the Center for Molecular Medicine Cologne (CMMC) lead the project that enables an individualized risk assessment for ADPKD patients and exceeds the accuracy of previous forecasting.
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A goal of the study is to examine the influence of existing therapies on the identified protein patterns. The further development of this method for a clinically usable test procedure is at the top of the team's agenda. The financial support takes place, among other things, by the Jörg Bernards Foundation and the German Research Foundation (DFG) as part of the Cluster of Excellence for Aging Research (CECAD) of the University of Cologne.
An additional aspect of the study concerns the strict guidelines that have been observed during research. Each participant has given a written informed approval and the study was approved by the Institutional Review Board of the University of Cologne. The ADPKD cohort is made up of patients who have been registered since 2015 and includes comprehensive clinical and laboratory chemical data.
ADPKD and their challenges
The autosomal dominant polycystic kidney disease is one of the most common genetic diseases of the kidneys. For those affected, there are often great kidneys with symptoms that range from chronic pain to blood in urine to more frequent kidney stones. According to estimates, 60 to 70 % of patients develop hypertension, while long-term consequences such as renal failure and finally kidney failure are not uncommon, as the Bleiben Sie informiert: Jeden Abend senden wir Ihnen die Artikel des Tages aus der Kategorie Koeln – übersichtlich als Liste.
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| Ort | Köln, Deutschland |
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